Skeletal muscle mitophagy in chronic disease
نویسندگان
چکیده
منابع مشابه
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a debilitating disease characterized by inflammation-induced airflow limitation and parenchymal destruction. In addition to pulmonary manifestations, patients with COPD develop systemic problems, including skeletal muscle and other organ-specific dysfunctions, nutritional abnormalities, weight loss, and adverse psychological responses. Patients wi...
متن کاملSkeletal muscle dysfunction in chronic obstructive pulmonary disease
Skeletal muscle dysfunction occurs in COPD patients and affects both ventilatory and non-ventilatory muscle groups. It represents a very important comorbidity that associates with poor quality of life and reduced survival, and results from a complex combination of functional, metabolic and anatomical alterations leading to suboptimal muscle work. Muscle atrophy, altered fiber type and metabolis...
متن کاملSkeletal muscle dysfunction: a ubiquitous outcome in chronic disease?
Skeletal muscle wasting is a debilitating consequence of respiratory disease, particularly well characterised in individuals with chronic obstructive pulmonary disease (COPD). However, it remains controversial whether peripheral muscle dysfunction is an intrinsic part of the respiratory disease process, or a generalised response to multiple atrophy stimuli. Such debate has not only informed the...
متن کاملSkeletal muscle pathology in chronic heart block.
Skeletal muscle samples, mainly from the deltoid, were studied morphologically and histochemically in 35 patients with chronic heart block and from nine elderly control subject. The average age of the first group was 67-7 (range 11-94) years. Abnormalities were present in 20 cases, no difference being found between patients with idiopathic and secondary heart block. In 15 samples there was incr...
متن کاملChronic Changes in Skeletal Muscle Histology
Background. Peripheral arterial disease (PAD) is associated with an impairment in exercise performance and muscle function that is not fully explained by the reduced leg blood flow during exercise. This study characterized the effects of PAD on muscle function, histology, and metabolism. Methods and Results. Twenty-six patients with PAD and six age-matched control subjects were studied. Ten of ...
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ژورنال
عنوان ژورنال: Current Opinion in Clinical Nutrition & Metabolic Care
سال: 2016
ISSN: 1363-1950
DOI: 10.1097/mco.0000000000000319